Assay Detail
Binding
CHEMBL4383516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 mins by Dixon plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.81 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432537 | — | — | 1 | 6.67 |
| CHEMBL1098875 | — | — | 1 | 6.47 |
| CHEMBL72165 | — | — | 1 | 6.45 |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | 6.24 |
| CHEMBL1812545 | — | — | 1 | 5.13 |
| CHEMBL3087010 | — | — | 1 | 5.08 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432537 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL1098875 | — | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL72165 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL306946 | TRYPTANTHRIN | Ki | = | 581.0 | nM | 6.24 |
| CHEMBL1812545 | — | Ki | = | 7470.0 | nM | 5.13 |
| CHEMBL3087010 | — | Ki | = | 8410.0 | nM | 5.08 |
| CHEMBL3545369 | EPACADOSTAT | Ki | = | 21700.0 | nM | 4.66 |