Assay Detail
Binding
CHEMBL4383517
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Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 mins by Dixon plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.63 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312537 | — | — | 1 | 6.08 |
| CHEMBL3086870 | — | — | 1 | 6.06 |
| CHEMBL3087009 | — | — | 1 | 6.00 |
| CHEMBL1276265 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312537 | — | Ki | = | 834.0 | nM | 6.08 |
| CHEMBL3086870 | — | Ki | = | 876.0 | nM | 6.06 |
| CHEMBL3087009 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1276265 | — | Ki | = | 42700.0 | nM | 4.37 |