Assay Detail
Binding
CHEMBL4383519
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Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.80 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72165 | — | — | 1 | 7.28 |
| CHEMBL3087009 | — | — | 1 | 7.23 |
| CHEMBL432537 | — | — | 1 | 7.21 |
| CHEMBL1098875 | — | — | 1 | 7.17 |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | 6.85 |
| CHEMBL312537 | — | — | 1 | 6.67 |
| CHEMBL3087010 | — | — | 1 | 6.64 |
| CHEMBL3086870 | — | — | 1 | 6.62 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 6.62 |
| CHEMBL1812545 | — | — | 1 | 6.40 |
| CHEMBL1276265 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72165 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3087009 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL432537 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1098875 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL306946 | TRYPTANTHRIN | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL312537 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL3087010 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL3086870 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL1812545 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL1276265 | — | IC50 | = | 733.0 | nM | 6.13 |