Assay Detail
Binding
CHEMBL4383710
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Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A<sub>4</sub> mimetics (sLXms).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.45 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4462922 | — | — | 1 | 9.15 |
| CHEMBL4436717 | — | — | 1 | 9.05 |
| CHEMBL4440913 | — | — | 1 | 8.66 |
| CHEMBL4434857 | — | — | 1 | 8.60 |
| CHEMBL4551559 | — | — | 1 | 8.37 |
| CHEMBL4536276 | — | — | 1 | 8.36 |
| CHEMBL4574711 | — | — | 1 | 7.73 |
| CHEMBL392438 | LIPOXIN A4 | — | 1 | 7.65 |
| CHEMBL4582724 | — | — | 1 | - |
| CHEMBL4534051 | — | — | 1 | - |
| CHEMBL4460558 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4462922 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4436717 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4440913 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4434857 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4551559 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4536276 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4574711 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL392438 | LIPOXIN A4 | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL4582724 | — | IC50 | - | — | - | |
| CHEMBL4534051 | — | IC50 | - | — | - | |
| CHEMBL4460558 | — | IC50 | - | — | - |