Assay Detail
Binding
CHEMBL4383871
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Inhibition of human factor Xa using S-2222 as substrate preincubated for 30 mins followed by substrate addition and measured for 20 mins
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of anthranilamide derivatives as potential factor Xa (fXa) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.89 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441346 | — | — | 1 | 8.46 |
| CHEMBL512351 | BETRIXABAN | 4.0 | 1 | 8.35 |
| CHEMBL4469752 | — | — | 1 | 8.32 |
| CHEMBL4469308 | — | — | 1 | 8.00 |
| CHEMBL4439939 | — | — | 1 | 7.75 |
| CHEMBL4530584 | — | — | 1 | 7.70 |
| CHEMBL4574442 | — | — | 1 | 7.62 |
| CHEMBL4586397 | — | — | 1 | 7.52 |
| CHEMBL4514976 | — | — | 1 | 7.35 |
| CHEMBL4450264 | — | — | 1 | 7.11 |
| CHEMBL4530694 | — | — | 1 | 6.75 |
| CHEMBL4459345 | — | — | 1 | 6.63 |
| CHEMBL4543553 | — | — | 1 | 6.61 |
| CHEMBL4438123 | — | — | 1 | 6.57 |
| CHEMBL4445604 | — | — | 1 | 6.50 |
| CHEMBL4572670 | — | — | 1 | 6.29 |
| CHEMBL4470300 | — | — | 1 | 6.18 |
| CHEMBL4439436 | — | — | 1 | 6.01 |
| CHEMBL4448395 | — | — | 1 | 5.97 |
| CHEMBL4525969 | — | — | 1 | 5.86 |
| CHEMBL4472454 | — | — | 1 | 5.81 |
| CHEMBL4472318 | — | — | 1 | 5.68 |
| CHEMBL4439648 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441346 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL512351 | BETRIXABAN | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4469752 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4469308 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4439939 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4530584 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4574442 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4586397 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4514976 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4450264 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4530694 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4459345 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL4543553 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL4438123 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL4445604 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL4572670 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL4470300 | — | IC50 | = | 653.0 | nM | 6.18 |
| CHEMBL4439436 | — | IC50 | = | 981.0 | nM | 6.01 |
| CHEMBL4448395 | — | IC50 | = | 1079.0 | nM | 5.97 |
| CHEMBL4525969 | — | IC50 | = | 1387.0 | nM | 5.86 |
| CHEMBL4472454 | — | IC50 | = | 1543.0 | nM | 5.81 |
| CHEMBL4472318 | — | IC50 | = | 2087.0 | nM | 5.68 |
| CHEMBL4439648 | — | IC50 | = | 3189.0 | nM | 5.50 |