Assay Detail
Binding
CHEMBL4383872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant thrombin expressed in HEK293 cells using S-2238 as substrate preincubated for 30 mins followed by substrate addition and measured for 20 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of anthranilamide derivatives as potential factor Xa (fXa) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.95 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441346 | — | — | 1 | 8.38 |
| CHEMBL4469752 | — | — | 1 | 8.15 |
| CHEMBL512351 | BETRIXABAN | 4.0 | 1 | 7.75 |
| CHEMBL4469308 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441346 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4469752 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL512351 | BETRIXABAN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4469308 | — | IC50 | = | 32.0 | nM | 7.50 |