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Assay Detail

CHEMBL4384569

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Functional
Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

A Pair of Enantiomeric Bis- seco-abietane Diterpenoids from Cryptomeria fortunei.
Feng L, Mándi A, Tang C, Kurtán T, Tang S, Ke CQ, Shen N, Lin G, Yao S, Ye Y.
J Nat Prod (2018) 81 : 2667 -2672
PubMed 30485090 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.24 10.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL58 MITOXANTRONE 4.0 1 10.62
CHEMBL4553108 1 4.80
CHEMBL4471013 1 4.76
CHEMBL4582949 1 4.68
CHEMBL4474104 1 4.66
CHEMBL4435892 1 4.59
CHEMBL4469547 1 4.38
CHEMBL4449186 1 4.34
CHEMBL4594115 1 4.31
CHEMBL494660 1 -
CHEMBL4482875 1 -
CHEMBL4469911 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL58 MITOXANTRONE IC50 = 0.024 nM 10.62
CHEMBL4553108 IC50 = 16000.0 nM 4.80
CHEMBL4471013 IC50 = 17200.0 nM 4.76
CHEMBL4582949 IC50 = 20800.0 nM 4.68
CHEMBL4474104 IC50 = 21700.0 nM 4.66
CHEMBL4435892 IC50 = 25700.0 nM 4.59
CHEMBL4469547 IC50 = 41200.0 nM 4.38
CHEMBL4449186 IC50 = 45500.0 nM 4.34
CHEMBL4594115 IC50 = 49400.0 nM 4.31
CHEMBL494660 IC50 > 100000.0 nM -
CHEMBL4482875 IC50 > 100000.0 nM -
CHEMBL4469911 IC50 > 100000.0 nM -