Assay Detail
Functional
CHEMBL4384824
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Antiproliferative activity against human HL60 cells by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.72 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330407 | — | — | 1 | 8.35 |
| CHEMBL4452846 | — | — | 1 | 6.70 |
| CHEMBL4559579 | — | — | 1 | 6.58 |
| CHEMBL4554182 | — | — | 1 | 6.52 |
| CHEMBL4541802 | — | — | 1 | 6.40 |
| CHEMBL4583364 | — | — | 1 | 6.16 |
| CHEMBL4545878 | — | — | 1 | 6.16 |
| CHEMBL4530765 | — | — | 1 | 6.05 |
| CHEMBL4453579 | — | — | 1 | 5.92 |
| CHEMBL4562093 | — | — | 1 | 5.78 |
| CHEMBL4465190 | — | — | 1 | 5.75 |
| CHEMBL4437831 | — | — | 1 | 5.75 |
| CHEMBL4518638 | — | — | 1 | 5.70 |
| CHEMBL4548509 | — | — | 1 | 5.66 |
| CHEMBL4457390 | — | — | 1 | 5.62 |
| CHEMBL4564346 | — | — | 1 | 5.62 |
| CHEMBL4552994 | — | — | 1 | 5.55 |
| CHEMBL4591781 | — | — | 1 | 5.52 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.40 |
| CHEMBL4470783 | — | — | 1 | 5.36 |
| CHEMBL4589675 | — | — | 1 | 5.35 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.30 |
| CHEMBL4519374 | — | — | 1 | 5.26 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.16 |
| CHEMBL4560318 | — | — | 1 | 5.10 |
| CHEMBL4458860 | — | — | 1 | 5.06 |
| CHEMBL4456186 | — | — | 1 | 5.02 |
| CHEMBL4473120 | — | — | 1 | 4.98 |
| CHEMBL4442200 | — | — | 1 | 4.97 |
| CHEMBL4588210 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330407 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4452846 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4559579 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4554182 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4541802 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4583364 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4545878 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4530765 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4453579 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4562093 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4465190 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4437831 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4518638 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4548509 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4457390 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4564346 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4552994 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4591781 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4470783 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4589675 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4519374 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL535 | SUNITINIB | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4560318 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4458860 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4456186 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4473120 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4442200 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4588210 | — | IC50 | = | 11300.0 | nM | 4.95 |