Assay Detail
ADMET
CHEMBL4384826
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Antiproliferative activity against HEK293 cells by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.97 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330407 | — | — | 1 | 8.15 |
| CHEMBL4452846 | — | — | 1 | 7.16 |
| CHEMBL4559579 | — | — | 1 | 6.70 |
| CHEMBL4562093 | — | — | 1 | 6.68 |
| CHEMBL4548509 | — | — | 1 | 6.62 |
| CHEMBL4583364 | — | — | 1 | 6.60 |
| CHEMBL4552994 | — | — | 1 | 6.52 |
| CHEMBL4530765 | — | — | 1 | 6.52 |
| CHEMBL4554182 | — | — | 1 | 6.52 |
| CHEMBL4541802 | — | — | 1 | 6.47 |
| CHEMBL4545878 | — | — | 1 | 6.40 |
| CHEMBL4564346 | — | — | 1 | 6.16 |
| CHEMBL4453579 | — | — | 1 | 6.05 |
| CHEMBL4465190 | — | — | 1 | 5.92 |
| CHEMBL4589675 | — | — | 1 | 5.89 |
| CHEMBL4591781 | — | — | 1 | 5.80 |
| CHEMBL4560318 | — | — | 1 | 5.79 |
| CHEMBL4437831 | — | — | 1 | 5.73 |
| CHEMBL4518638 | — | — | 1 | 5.68 |
| CHEMBL4458860 | — | — | 1 | 5.54 |
| CHEMBL4457390 | — | — | 1 | 5.47 |
| CHEMBL4470783 | — | — | 1 | 5.46 |
| CHEMBL4588210 | — | — | 1 | 5.30 |
| CHEMBL4442200 | — | — | 1 | 5.30 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.30 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.30 |
| CHEMBL4456186 | — | — | 1 | 5.24 |
| CHEMBL4519374 | — | — | 1 | 5.22 |
| CHEMBL4473120 | — | — | 1 | 5.03 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330407 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4452846 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4559579 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4562093 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4548509 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4583364 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4552994 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4530765 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4554182 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4541802 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4545878 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4564346 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4453579 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4465190 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4589675 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4591781 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4560318 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4437831 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL4518638 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4458860 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4457390 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4470783 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4588210 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL4442200 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL535 | SUNITINIB | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4456186 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4519374 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4473120 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 25000.0 | nM | 4.60 |