Assay Detail
Binding
CHEMBL4385036
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Sprague-Dawley rat liver MAO-B using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by resorufin-based fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.32 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450595 | — | — | 1 | 8.38 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 8.37 |
| CHEMBL4439889 | — | — | 1 | 8.31 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.21 |
| CHEMBL3707394 | SEMBRAGILINE | 2.0 | 1 | 7.83 |
| CHEMBL4450144 | — | — | 1 | 7.07 |
| CHEMBL4532884 | — | — | 1 | 6.82 |
| CHEMBL4456254 | — | — | 1 | 6.80 |
| CHEMBL4467747 | — | — | 1 | 6.65 |
| CHEMBL4451278 | — | — | 1 | 6.24 |
| CHEMBL4441316 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450595 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL887 | RASAGILINE | IC50 | = | 4.31 | nM | 8.37 |
| CHEMBL4439889 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL972 | SELEGILINE | IC50 | = | 6.11 | nM | 8.21 |
| CHEMBL3707394 | SEMBRAGILINE | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4450144 | — | IC50 | = | 85.5 | nM | 7.07 |
| CHEMBL4532884 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4456254 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4467747 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL4451278 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL4441316 | — | IC50 | = | 1303.0 | nM | 5.88 |