Assay Detail
Binding
CHEMBL4385494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BTK in human whole blood assessed as reduction in anti-human IgE antibody-stimulated histamine release pretreated for 2 hrs followed by anti-human IgE antibody-stimulation and measured after 30 mins by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.31 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456283 | — | — | 1 | 7.68 |
| CHEMBL4456974 | — | — | 1 | 7.38 |
| CHEMBL4462332 | — | — | 1 | 7.30 |
| CHEMBL4560385 | — | — | 1 | 7.19 |
| CHEMBL4469663 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456283 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4456974 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4462332 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4560385 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4469663 | — | IC50 | = | 95.0 | nM | 7.02 |