Assay Detail
Binding
CHEMBL4385717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His6-tagged recombinant full length human N-terminal PI3Kbeta expressed in baculovirus infected Sf21 cells using lipid substrate incubated for 2 hrs by ADP-Glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kδ-selective inhibitors for treating B-cell-mediated malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.47 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453364 | — | — | 1 | 7.26 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 6.81 |
| CHEMBL4471020 | — | — | 1 | 6.77 |
| CHEMBL4468379 | — | — | 1 | 6.12 |
| CHEMBL4520088 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453364 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4471020 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4468379 | — | IC50 | = | 766.0 | nM | 6.12 |
| CHEMBL4520088 | — | IC50 | = | 3990.0 | nM | 5.40 |