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Assay Detail

CHEMBL4385971

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Functional
Antiproliferative activity against human MOLM13 cells harboring FLT3-ITD mutant measured after 72 hrs by MTT assay
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MOLM-13
Confidence 1 — Organism
Curated By Autocuration

Target

MOLM-13 (CHEMBL3706572) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia.
Yuan X, Chen Y, Zhang W, He J, Lei L, Tang M, Liu J, Li M, Dou C, Yang T, Yang L, Yang S, Wei Y, Peng A, Niu T, Xiang M, Ye H, Chen L.
J Med Chem (2019) 62 : 4158 -4173
PubMed 30939008 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 9.19 10.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4557634 — — 1 10.85
CHEMBL4439404 — — 1 10.66
CHEMBL4440175 — — 1 10.42
CHEMBL4575519 — — 1 10.31
CHEMBL4526888 — — 1 10.09
CHEMBL4553847 — — 1 9.93
CHEMBL4475375 — — 1 9.87
CHEMBL4541344 — — 1 9.85
CHEMBL4572972 — — 1 9.84
CHEMBL4572804 — — 1 9.71
CHEMBL4459941 — — 1 9.58
CHEMBL4483045 — — 1 9.41
CHEMBL4435457 — — 1 9.28
CHEMBL4532475 — — 1 9.24
CHEMBL4454804 — — 1 9.19
CHEMBL4461531 — — 1 9.14
CHEMBL4441875 — — 1 9.13
CHEMBL4435360 — — 1 9.01
CHEMBL4569015 — — 1 8.99
CHEMBL4591906 — — 1 8.97
CHEMBL4515336 — — 1 8.94
CHEMBL4539069 — — 1 8.94
CHEMBL4449006 — — 1 8.85
CHEMBL4558160 — — 1 8.84
CHEMBL4529106 — — 1 8.82
CHEMBL4439044 — — 1 8.81
CHEMBL576982 QUIZARTINIB 4.0 1 8.72
CHEMBL4586009 — — 1 8.71
CHEMBL4553033 — — 1 8.69
CHEMBL4457542 — — 1 8.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4557634 — IC50 = 0.014 nM 10.85
CHEMBL4439404 — IC50 = 0.022 nM 10.66
CHEMBL4440175 — IC50 = 0.038 nM 10.42
CHEMBL4575519 — IC50 = 0.049 nM 10.31
CHEMBL4526888 — IC50 = 0.081 nM 10.09
CHEMBL4553847 — IC50 = 0.117 nM 9.93
CHEMBL4475375 — IC50 = 0.134 nM 9.87
CHEMBL4541344 — IC50 = 0.14 nM 9.85
CHEMBL4572972 — IC50 = 0.144 nM 9.84
CHEMBL4572804 — IC50 = 0.193 nM 9.71
CHEMBL4459941 — IC50 = 0.262 nM 9.58
CHEMBL4483045 — IC50 = 0.389 nM 9.41
CHEMBL4435457 — IC50 = 0.52 nM 9.28
CHEMBL4532475 — IC50 = 0.58 nM 9.24
CHEMBL4454804 — IC50 = 0.65 nM 9.19
CHEMBL4461531 — IC50 = 0.73 nM 9.14
CHEMBL4441875 — IC50 = 0.736 nM 9.13
CHEMBL4435360 — IC50 = 0.971 nM 9.01
CHEMBL4569015 — IC50 = 1.025 nM 8.99
CHEMBL4591906 — IC50 = 1.061 nM 8.97
CHEMBL4515336 — IC50 = 1.153 nM 8.94
CHEMBL4539069 — IC50 = 1.145 nM 8.94
CHEMBL4449006 — IC50 = 1.425 nM 8.85
CHEMBL4558160 — IC50 = 1.45 nM 8.84
CHEMBL4529106 — IC50 = 1.511 nM 8.82
CHEMBL4439044 — IC50 = 1.55 nM 8.81
CHEMBL576982 QUIZARTINIB IC50 = 1.885 nM 8.72
CHEMBL4586009 — IC50 = 1.946 nM 8.71
CHEMBL4553033 — IC50 = 2.046 nM 8.69
CHEMBL4457542 — IC50 = 2.222 nM 8.65
CHEMBL4472511 — IC50 = 2.33 nM 8.63
CHEMBL4551816 — IC50 = 2.495 nM 8.60
CHEMBL4441629 — IC50 = 2.56 nM 8.59
CHEMBL4468986 — IC50 = 2.767 nM 8.56
CHEMBL4442278 — IC50 = 2.855 nM 8.54
CHEMBL4533761 — IC50 = 3.771 nM 8.42
CHEMBL4449318 — IC50 = 4.435 nM 8.35
CHEMBL4438587 — IC50 = 10.6 nM 7.97
CHEMBL4551114 — IC50 = 0.007 nM -
CHEMBL4517711 — IC50 < 0.001 nM -