Assay Detail
Functional
CHEMBL4385973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BAF3 cells harboring FLT3-ITD mutant measured after 72 hrs by MTT assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 8.55 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4517711 | — | — | 1 | 9.80 |
| CHEMBL4551114 | — | — | 1 | 9.60 |
| CHEMBL4439404 | — | — | 1 | 9.04 |
| CHEMBL4572972 | — | — | 1 | 9.04 |
| CHEMBL4575519 | — | — | 1 | 9.02 |
| CHEMBL4440175 | — | — | 1 | 9.01 |
| CHEMBL4572804 | — | — | 1 | 9.00 |
| CHEMBL4515336 | — | — | 1 | 8.97 |
| CHEMBL4461531 | — | — | 1 | 8.90 |
| CHEMBL4526888 | — | — | 1 | 8.89 |
| CHEMBL4557634 | — | — | 1 | 8.84 |
| CHEMBL4435457 | — | — | 1 | 8.80 |
| CHEMBL4475375 | — | — | 1 | 8.79 |
| CHEMBL4459941 | — | — | 1 | 8.78 |
| CHEMBL4541344 | — | — | 1 | 8.76 |
| CHEMBL4483045 | — | — | 1 | 8.61 |
| CHEMBL4441875 | — | — | 1 | 8.56 |
| CHEMBL4454804 | — | — | 1 | 8.52 |
| CHEMBL4586009 | — | — | 1 | 8.51 |
| CHEMBL4553847 | — | — | 1 | 8.49 |
| CHEMBL4438587 | — | — | 1 | 8.45 |
| CHEMBL4472511 | — | — | 1 | 8.37 |
| CHEMBL4439044 | — | — | 1 | 8.34 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 8.31 |
| CHEMBL4591906 | — | — | 1 | 8.31 |
| CHEMBL4569015 | — | — | 1 | 8.29 |
| CHEMBL4435360 | — | — | 1 | 8.28 |
| CHEMBL4558160 | — | — | 1 | 8.27 |
| CHEMBL4532475 | — | — | 1 | 8.25 |
| CHEMBL4449006 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4517711 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL4551114 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4572972 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL4439404 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL4575519 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL4440175 | — | IC50 | = | 0.97 | nM | 9.01 |
| CHEMBL4572804 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL4515336 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL4461531 | — | IC50 | = | 1.27 | nM | 8.90 |
| CHEMBL4526888 | — | IC50 | = | 1.28 | nM | 8.89 |
| CHEMBL4557634 | — | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL4435457 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4475375 | — | IC50 | = | 1.62 | nM | 8.79 |
| CHEMBL4459941 | — | IC50 | = | 1.66 | nM | 8.78 |
| CHEMBL4541344 | — | IC50 | = | 1.73 | nM | 8.76 |
| CHEMBL4483045 | — | IC50 | = | 2.48 | nM | 8.61 |
| CHEMBL4441875 | — | IC50 | = | 2.72 | nM | 8.56 |
| CHEMBL4454804 | — | IC50 | = | 3.04 | nM | 8.52 |
| CHEMBL4586009 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4553847 | — | IC50 | = | 3.21 | nM | 8.49 |
| CHEMBL4438587 | — | IC50 | = | 3.59 | nM | 8.45 |
| CHEMBL4472511 | — | IC50 | = | 4.26 | nM | 8.37 |
| CHEMBL4439044 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 4.94 | nM | 8.31 |
| CHEMBL4591906 | — | IC50 | = | 4.92 | nM | 8.31 |
| CHEMBL4569015 | — | IC50 | = | 5.09 | nM | 8.29 |
| CHEMBL4435360 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4558160 | — | IC50 | = | 5.41 | nM | 8.27 |
| CHEMBL4532475 | — | IC50 | = | 5.57 | nM | 8.25 |
| CHEMBL4449006 | — | IC50 | = | 5.69 | nM | 8.24 |
| CHEMBL4457542 | — | IC50 | = | 5.95 | nM | 8.22 |
| CHEMBL4442278 | — | IC50 | = | 6.06 | nM | 8.22 |
| CHEMBL4539069 | — | IC50 | = | 6.18 | nM | 8.21 |
| CHEMBL4529106 | — | IC50 | = | 7.25 | nM | 8.14 |
| CHEMBL4551816 | — | IC50 | = | 8.45 | nM | 8.07 |
| CHEMBL4553033 | — | IC50 | = | 8.65 | nM | 8.06 |
| CHEMBL4468986 | — | IC50 | = | 8.67 | nM | 8.06 |
| CHEMBL4441629 | — | IC50 | = | 8.67 | nM | 8.06 |
| CHEMBL4449318 | — | IC50 | = | 8.95 | nM | 8.05 |
| CHEMBL4533761 | — | IC50 | = | 20.71 | nM | 7.68 |