Assay Detail
Functional
CHEMBL4385974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BAF3 cells harboring FLT3-ITD-F691L mutant measured after 72 hrs by MTT assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.40 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4517711 | — | — | 1 | 8.63 |
| CHEMBL4440175 | — | — | 1 | 8.44 |
| CHEMBL4526888 | — | — | 1 | 8.05 |
| CHEMBL4461531 | — | — | 1 | 8.01 |
| CHEMBL4551114 | — | — | 1 | 7.97 |
| CHEMBL4435360 | — | — | 1 | 7.90 |
| CHEMBL4439404 | — | — | 1 | 7.89 |
| CHEMBL4541344 | — | — | 1 | 7.87 |
| CHEMBL4459941 | — | — | 1 | 7.86 |
| CHEMBL4483045 | — | — | 1 | 7.79 |
| CHEMBL4435457 | — | — | 1 | 7.71 |
| CHEMBL4586009 | — | — | 1 | 7.55 |
| CHEMBL4557634 | — | — | 1 | 7.55 |
| CHEMBL4572972 | — | — | 1 | 7.54 |
| CHEMBL4575519 | — | — | 1 | 7.54 |
| CHEMBL4472511 | — | — | 1 | 7.50 |
| CHEMBL4572804 | — | — | 1 | 7.49 |
| CHEMBL4515336 | — | — | 1 | 7.46 |
| CHEMBL4532475 | — | — | 1 | 7.41 |
| CHEMBL4439044 | — | — | 1 | 7.37 |
| CHEMBL4558160 | — | — | 1 | 7.30 |
| CHEMBL4539069 | — | — | 1 | 7.29 |
| CHEMBL4569015 | — | — | 1 | 7.24 |
| CHEMBL4441875 | — | — | 1 | 7.14 |
| CHEMBL4454804 | — | — | 1 | 7.08 |
| CHEMBL4438587 | — | — | 1 | 7.07 |
| CHEMBL4475375 | — | — | 1 | 7.07 |
| CHEMBL4591906 | — | — | 1 | 7.04 |
| CHEMBL4529106 | — | — | 1 | 7.04 |
| CHEMBL4553847 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4517711 | — | IC50 | = | 2.35 | nM | 8.63 |
| CHEMBL4440175 | — | IC50 | = | 3.61 | nM | 8.44 |
| CHEMBL4526888 | — | IC50 | = | 8.92 | nM | 8.05 |
| CHEMBL4461531 | — | IC50 | = | 9.84 | nM | 8.01 |
| CHEMBL4551114 | — | IC50 | = | 10.71 | nM | 7.97 |
| CHEMBL4435360 | — | IC50 | = | 12.56 | nM | 7.90 |
| CHEMBL4439404 | — | IC50 | = | 12.99 | nM | 7.89 |
| CHEMBL4541344 | — | IC50 | = | 13.63 | nM | 7.87 |
| CHEMBL4459941 | — | IC50 | = | 13.88 | nM | 7.86 |
| CHEMBL4483045 | — | IC50 | = | 16.08 | nM | 7.79 |
| CHEMBL4435457 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL4586009 | — | IC50 | = | 28.23 | nM | 7.55 |
| CHEMBL4557634 | — | IC50 | = | 27.92 | nM | 7.55 |
| CHEMBL4572972 | — | IC50 | = | 28.53 | nM | 7.54 |
| CHEMBL4575519 | — | IC50 | = | 28.65 | nM | 7.54 |
| CHEMBL4472511 | — | IC50 | = | 31.46 | nM | 7.50 |
| CHEMBL4572804 | — | IC50 | = | 32.12 | nM | 7.49 |
| CHEMBL4515336 | — | IC50 | = | 34.81 | nM | 7.46 |
| CHEMBL4532475 | — | IC50 | = | 39.39 | nM | 7.41 |
| CHEMBL4439044 | — | IC50 | = | 42.66 | nM | 7.37 |
| CHEMBL4558160 | — | IC50 | = | 50.25 | nM | 7.30 |
| CHEMBL4539069 | — | IC50 | = | 51.17 | nM | 7.29 |
| CHEMBL4569015 | — | IC50 | = | 57.79 | nM | 7.24 |
| CHEMBL4441875 | — | IC50 | = | 72.09 | nM | 7.14 |
| CHEMBL4454804 | — | IC50 | = | 82.43 | nM | 7.08 |
| CHEMBL4438587 | — | IC50 | = | 85.99 | nM | 7.07 |
| CHEMBL4475375 | — | IC50 | = | 85.02 | nM | 7.07 |
| CHEMBL4591906 | — | IC50 | = | 91.8 | nM | 7.04 |
| CHEMBL4529106 | — | IC50 | = | 90.87 | nM | 7.04 |
| CHEMBL4553847 | — | IC50 | = | 98.6 | nM | 7.01 |
| CHEMBL4551816 | — | IC50 | = | 133.5 | nM | 6.88 |
| CHEMBL4553033 | — | IC50 | = | 147.9 | nM | 6.83 |
| CHEMBL4457542 | — | IC50 | = | 200.3 | nM | 6.70 |
| CHEMBL4449006 | — | IC50 | = | 208.7 | nM | 6.68 |
| CHEMBL4468986 | — | IC50 | = | 216.5 | nM | 6.67 |
| CHEMBL4442278 | — | IC50 | = | 228.1 | nM | 6.64 |
| CHEMBL4533761 | — | IC50 | = | 252.7 | nM | 6.60 |
| CHEMBL576982 | QUIZARTINIB | IC50 | > | 1000.0 | nM | - |
| CHEMBL4449318 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4441629 | — | IC50 | > | 200.0 | nM | - |