Assay Detail
Functional
CHEMBL4385975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BAF3 cells harboring FLT3-ITD-D835V mutant measured after 72 hrs by MTT assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.21 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4517711 | — | — | 1 | 8.32 |
| CHEMBL4440175 | — | — | 1 | 8.04 |
| CHEMBL4526888 | — | — | 1 | 7.91 |
| CHEMBL4435360 | — | — | 1 | 7.91 |
| CHEMBL4541344 | — | — | 1 | 7.83 |
| CHEMBL4551114 | — | — | 1 | 7.74 |
| CHEMBL4439404 | — | — | 1 | 7.68 |
| CHEMBL4459941 | — | — | 1 | 7.67 |
| CHEMBL4572972 | — | — | 1 | 7.64 |
| CHEMBL4435457 | — | — | 1 | 7.61 |
| CHEMBL4586009 | — | — | 1 | 7.54 |
| CHEMBL4529106 | — | — | 1 | 7.43 |
| CHEMBL4441875 | — | — | 1 | 7.38 |
| CHEMBL4557634 | — | — | 1 | 7.33 |
| CHEMBL4575519 | — | — | 1 | 7.30 |
| CHEMBL4454804 | — | — | 1 | 7.29 |
| CHEMBL4515336 | — | — | 1 | 7.28 |
| CHEMBL4439044 | — | — | 1 | 7.26 |
| CHEMBL4572804 | — | — | 1 | 7.21 |
| CHEMBL4532475 | — | — | 1 | 7.16 |
| CHEMBL4558160 | — | — | 1 | 7.07 |
| CHEMBL4539069 | — | — | 1 | 7.06 |
| CHEMBL4461531 | — | — | 1 | 7.06 |
| CHEMBL4569015 | — | — | 1 | 7.03 |
| CHEMBL4551816 | — | — | 1 | 7.02 |
| CHEMBL4483045 | — | — | 1 | 6.99 |
| CHEMBL4449006 | — | — | 1 | 6.95 |
| CHEMBL4472511 | — | — | 1 | 6.95 |
| CHEMBL4457542 | — | — | 1 | 6.85 |
| CHEMBL4441629 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4517711 | — | IC50 | = | 4.83 | nM | 8.32 |
| CHEMBL4440175 | — | IC50 | = | 9.17 | nM | 8.04 |
| CHEMBL4435360 | — | IC50 | = | 12.19 | nM | 7.91 |
| CHEMBL4526888 | — | IC50 | = | 12.39 | nM | 7.91 |
| CHEMBL4541344 | — | IC50 | = | 14.74 | nM | 7.83 |
| CHEMBL4551114 | — | IC50 | = | 18.01 | nM | 7.74 |
| CHEMBL4439404 | — | IC50 | = | 20.71 | nM | 7.68 |
| CHEMBL4459941 | — | IC50 | = | 21.15 | nM | 7.67 |
| CHEMBL4572972 | — | IC50 | = | 23.09 | nM | 7.64 |
| CHEMBL4435457 | — | IC50 | = | 24.64 | nM | 7.61 |
| CHEMBL4586009 | — | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL4529106 | — | IC50 | = | 36.8 | nM | 7.43 |
| CHEMBL4441875 | — | IC50 | = | 41.49 | nM | 7.38 |
| CHEMBL4557634 | — | IC50 | = | 46.25 | nM | 7.33 |
| CHEMBL4575519 | — | IC50 | = | 50.14 | nM | 7.30 |
| CHEMBL4454804 | — | IC50 | = | 51.85 | nM | 7.29 |
| CHEMBL4515336 | — | IC50 | = | 52.38 | nM | 7.28 |
| CHEMBL4439044 | — | IC50 | = | 55.37 | nM | 7.26 |
| CHEMBL4572804 | — | IC50 | = | 61.84 | nM | 7.21 |
| CHEMBL4532475 | — | IC50 | = | 69.7 | nM | 7.16 |
| CHEMBL4558160 | — | IC50 | = | 84.41 | nM | 7.07 |
| CHEMBL4461531 | — | IC50 | = | 86.69 | nM | 7.06 |
| CHEMBL4539069 | — | IC50 | = | 86.43 | nM | 7.06 |
| CHEMBL4569015 | — | IC50 | = | 93.7 | nM | 7.03 |
| CHEMBL4551816 | — | IC50 | = | 95.4 | nM | 7.02 |
| CHEMBL4483045 | — | IC50 | = | 102.5 | nM | 6.99 |
| CHEMBL4449006 | — | IC50 | = | 111.5 | nM | 6.95 |
| CHEMBL4472511 | — | IC50 | = | 111.5 | nM | 6.95 |
| CHEMBL4457542 | — | IC50 | = | 139.8 | nM | 6.85 |
| CHEMBL4441629 | — | IC50 | = | 155.67 | nM | 6.81 |
| CHEMBL4438587 | — | IC50 | = | 166.5 | nM | 6.78 |
| CHEMBL4475375 | — | IC50 | = | 170.23 | nM | 6.77 |
| CHEMBL4553847 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4591906 | — | IC50 | = | 175.6 | nM | 6.75 |
| CHEMBL4442278 | — | IC50 | = | 185.3 | nM | 6.73 |
| CHEMBL4533761 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4468986 | — | IC50 | = | 305.3 | nM | 6.51 |
| CHEMBL4553033 | — | IC50 | = | 361.1 | nM | 6.44 |
| CHEMBL4449318 | — | IC50 | = | 385.4 | nM | 6.41 |
| CHEMBL576982 | QUIZARTINIB | IC50 | > | 1000.0 | nM | - |