Assay Detail
Binding
CHEMBL4386404
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Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.92 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4578278 | — | — | 1 | 8.40 |
| CHEMBL2103863 | ABEXINOSTAT | 3.0 | 1 | 8.40 |
| CHEMBL4532181 | — | — | 1 | 8.30 |
| CHEMBL4066920 | — | — | 1 | 8.30 |
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 8.00 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.90 |
| CHEMBL3907295 | — | — | 1 | 7.70 |
| CHEMBL4470067 | — | — | 1 | 7.70 |
| CHEMBL4541796 | — | — | 1 | 7.60 |
| CHEMBL3958794 | — | — | 1 | 7.20 |
| CHEMBL4466930 | — | — | 1 | 7.10 |
| CHEMBL4066043 | — | — | 1 | 7.10 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 7.00 |
| CHEMBL4445881 | — | — | 1 | 6.90 |
| CHEMBL598797 | CUDC-101 | 1.0 | 1 | 6.90 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 6.90 |
| CHEMBL4534503 | — | — | 1 | 6.80 |
| CHEMBL2018451 | — | — | 1 | 6.70 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.70 |
| CHEMBL3971436 | — | — | 1 | 6.50 |
| CHEMBL4438279 | — | — | 1 | 6.50 |
| CHEMBL511749 | — | — | 1 | 6.50 |
| CHEMBL4562244 | — | — | 1 | 6.30 |
| CHEMBL4531802 | — | — | 1 | 6.20 |
| CHEMBL4475240 | — | — | 1 | 6.00 |
| CHEMBL1851943 | PRACINOSTAT | 3.0 | 1 | 5.80 |
| CHEMBL2170166 | — | — | 1 | 5.70 |
| CHEMBL4468860 | — | — | 1 | 5.30 |
| CHEMBL2170177 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4578278 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL2103863 | ABEXINOSTAT | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4532181 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL4066920 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL2105763 | QUISINOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3907295 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4470067 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4541796 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3958794 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4466930 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4066043 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4445881 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL598797 | CUDC-101 | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4534503 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL2018451 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL3971436 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4438279 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL511749 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4562244 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4531802 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4475240 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1851943 | PRACINOSTAT | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL2170166 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4468860 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL2170177 | — | IC50 | = | 39810.72 | nM | 4.40 |