Assay Detail
ADMET
CHEMBL4386831
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Cytotoxicity against human bone marrow cells incubated for 3 days by CellTiter-Glo luminescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Bone marrow cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.51 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221919 | — | — | 1 | 5.51 |
| CHEMBL65742 | — | — | 1 | - |
| CHEMBL2313117 | — | — | 1 | - |
| CHEMBL4467546 | — | — | 1 | - |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221919 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL65742 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2313117 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4467546 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1448 | NICLOSAMIDE | IC50 | > | 10000.0 | nM | - |