Assay Detail
Functional
CHEMBL4387154
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Cytotoxicity against human BT549 cells assessed as reduction in cell count after 24 hrs by high-throughput microscopy
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.39 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440980 | — | — | 1 | 5.41 |
| CHEMBL4545456 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440980 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4545456 | — | EC50 | = | 4400.0 | nM | 5.36 |