Assay Detail
Binding
CHEMBL4387399
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Inhibition of recombinant Leishmania amazonensis arginase expressed in Escherichia coli assessed as reduction in urea production using L-arginine as substrate by Berthelot colorimetric method relative to control
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania amazonensis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenylhydrazides as inhibitors of Leishmania amazonensis arginase and antileishmanial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.67 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204512 | — | — | 1 | 4.92 |
| CHEMBL4216180 | — | — | 1 | 4.92 |
| CHEMBL4530523 | — | — | 1 | 4.43 |
| CHEMBL4574177 | — | — | 1 | 4.42 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | - |
| CHEMBL4459163 | — | — | 1 | - |
| CHEMBL4546693 | — | — | 1 | - |
| CHEMBL4562829 | — | — | 1 | - |
| CHEMBL4216693 | — | — | 1 | - |
| CHEMBL4211729 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204512 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4216180 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4530523 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4574177 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | - | — | - | |
| CHEMBL4459163 | — | IC50 | - | — | - | |
| CHEMBL4546693 | — | IC50 | - | — | - | |
| CHEMBL4562829 | — | IC50 | - | — | - | |
| CHEMBL4216693 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4211729 | — | IC50 | > | 100000.0 | nM | - |