Assay Detail
Functional
CHEMBL4387482
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Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
X-ray crystal structures, density functional theory and docking on deacetylase enzyme for antiproliferative activity of hispolon derivatives on HCT116 colon cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.00 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762214 | — | — | 1 | 5.85 |
| CHEMBL3402166 | — | — | 1 | 5.33 |
| CHEMBL1762212 | — | — | 1 | 5.28 |
| CHEMBL3979030 | — | — | 1 | 5.07 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.98 |
| CHEMBL3402167 | — | — | 1 | 4.92 |
| CHEMBL3978718 | — | — | 1 | 4.61 |
| CHEMBL3949987 | — | — | 1 | 4.54 |
| CHEMBL3402165 | — | — | 1 | 4.44 |
| CHEMBL1762213 | — | — | 1 | - |
| CHEMBL3402175 | — | — | 1 | - |
| CHEMBL3402177 | — | — | 1 | - |
| CHEMBL4567710 | — | — | 1 | - |
| CHEMBL4458666 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762214 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3402166 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1762212 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3979030 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL140 | CURCUMIN | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3402167 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL3978718 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL3949987 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL3402165 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL1762213 | — | IC50 | = | 182500.0 | nM | - |
| CHEMBL3402175 | — | IC50 | = | 213300.0 | nM | - |
| CHEMBL3402177 | — | IC50 | = | 215000.0 | nM | - |
| CHEMBL4567710 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL4458666 | — | IC50 | = | 139000.0 | nM | - |