Assay Detail
Binding
CHEMBL4387673
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3KD (unknown origin) by HTRF assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.42 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4434674 | — | — | 1 | 9.48 |
| CHEMBL4452905 | — | — | 1 | 9.00 |
| CHEMBL4449778 | — | — | 1 | 8.72 |
| CHEMBL4517406 | — | — | 1 | 8.14 |
| CHEMBL4524356 | — | — | 1 | 8.00 |
| CHEMBL4575776 | — | — | 1 | 8.00 |
| CHEMBL4440095 | — | — | 1 | 7.96 |
| CHEMBL4474516 | — | — | 1 | 7.92 |
| CHEMBL4461221 | — | — | 1 | 7.70 |
| CHEMBL4515312 | — | — | 1 | 7.64 |
| CHEMBL4562428 | — | — | 1 | 7.62 |
| CHEMBL4549113 | — | — | 1 | 7.57 |
| CHEMBL4435654 | — | — | 1 | 7.50 |
| CHEMBL4436827 | — | — | 1 | 7.48 |
| CHEMBL4522603 | — | — | 1 | 7.47 |
| CHEMBL4451433 | — | — | 1 | 7.43 |
| CHEMBL4586842 | — | — | 1 | 7.37 |
| CHEMBL4475748 | — | — | 1 | 7.24 |
| CHEMBL4438805 | — | — | 1 | 7.22 |
| CHEMBL4562183 | — | — | 1 | 7.21 |
| CHEMBL4456087 | — | — | 1 | 7.05 |
| CHEMBL4452117 | — | — | 1 | 7.03 |
| CHEMBL4468849 | — | — | 1 | 6.82 |
| CHEMBL4471570 | — | — | 1 | 6.75 |
| CHEMBL4549128 | — | — | 1 | 6.75 |
| CHEMBL4447681 | — | — | 1 | 6.46 |
| CHEMBL4435568 | — | — | 1 | 6.43 |
| CHEMBL4455359 | — | — | 1 | 6.28 |
| CHEMBL4436565 | — | — | 1 | 6.27 |
| CHEMBL4444468 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4434674 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL4452905 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4449778 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4517406 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4524356 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4575776 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4440095 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4474516 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4461221 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4515312 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4562428 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4549113 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4435654 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4436827 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4522603 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4451433 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4586842 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4475748 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4438805 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4562183 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4456087 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4452117 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4468849 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4471570 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4549128 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4447681 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL4435568 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL4455359 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4436565 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4444468 | — | IC50 | = | 689.0 | nM | 6.16 |
| CHEMBL4454950 | — | IC50 | > | 10000.0 | nM | - |