Compound Detail
CHEMBL4449778
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Basic Information
| ChEMBL ID | CHEMBL4449778 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BWZJQTMIXIJENC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
410.5
MW (Da)
4.17
ALogP
6
HBA
1
HBD
85.1
PSA (Ų)
0.55
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 8.72 | 8.72 | 1.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 1.9 | nM | 8.72 | Inhibition of PI3KD (unknown origin) by HTRF assay | 31416665 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31416665 | 10.1016/j.bmcl.2019.08.004 | Unchecked | 3 |
| 31416665 | 10.1016/j.bmcl.2019.08.004 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1 |
Data from ChEMBL 36 via Core Engine