Assay Detail
Functional
CHEMBL4388501
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Growth inhibition of human NCI-H2228 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2228 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis of orally bioavailable novel anaplastic lymphoma kinase (ALK) inhibitor diphenylaminopyrimidine analogs and efficacy study on NCI-H2228 xenografts mice model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.12 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464582 | — | — | 1 | 7.38 |
| CHEMBL4451829 | — | — | 1 | 7.34 |
| CHEMBL4542506 | — | — | 1 | 7.01 |
| CHEMBL4468931 | — | — | 1 | 7.01 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 7.01 |
| CHEMBL4476089 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464582 | — | IC50 | = | 41.3 | nM | 7.38 |
| CHEMBL4451829 | — | IC50 | = | 45.5 | nM | 7.34 |
| CHEMBL4542506 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4468931 | — | IC50 | = | 98.5 | nM | 7.01 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4476089 | — | IC50 | = | 111.3 | nM | 6.95 |