Assay Detail
Binding
CHEMBL4388560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under full equilibrating condition by scanKINETIC assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lead generation of 1,2-dithiolanes as exon 19 and exon 21 mutant EGFR tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.62 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4517633 | — | — | 1 | 9.15 |
| CHEMBL4513286 | — | — | 1 | 8.68 |
| CHEMBL4457447 | — | — | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4517633 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL4513286 | — | Kd | = | 2.1 | nM | 8.68 |
| CHEMBL4457447 | — | Kd | = | 9.6 | nM | 8.02 |