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Assay Detail

CHEMBL4388635

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Binding
Inhibition of human PTPN1 expressed in Escherichia coli Rosetta 2 (DE3) using pNPP as substrate after 45 mins by spectrophotometric method
ChEMBL ↗
146
Total Activities
146
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SM.
Bioorg Med Chem Lett (2019) 29 : 1665 -1672
PubMed 31047750 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 146 4.65 5.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3934460 — — 1 5.50
CHEMBL4171392 — — 1 5.37
CHEMBL4446055 — — 1 5.31
CHEMBL4590591 — — 1 5.27
CHEMBL3924724 — — 1 5.20
CHEMBL3908434 — — 1 5.19
CHEMBL4447455 — — 1 5.19
CHEMBL4453551 — — 1 5.19
CHEMBL3951335 — — 1 5.16
CHEMBL4542408 — — 1 5.16
CHEMBL4518473 — — 1 5.16
CHEMBL4548710 — — 1 5.16
CHEMBL4533148 — — 1 5.14
CHEMBL4169499 — — 1 5.12
CHEMBL4166077 — — 1 5.12
CHEMBL4161487 — — 1 5.12
CHEMBL3980253 — — 1 5.10
CHEMBL4167333 — — 1 5.10
CHEMBL4565697 — — 1 5.10
CHEMBL4531689 — — 1 5.10
CHEMBL3975683 — — 1 5.09
CHEMBL4467368 — — 1 5.08
CHEMBL4547546 — — 1 5.07
CHEMBL4513892 — — 1 5.06
CHEMBL4161583 — — 1 5.03
CHEMBL3960743 — — 1 5.00
CHEMBL3912547 — — 1 5.00
CHEMBL4562570 — — 1 5.00
CHEMBL4526007 — — 1 5.00
CHEMBL3979736 — — 1 4.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3934460 — IC50 = 3200.0 nM 5.50
CHEMBL4171392 — IC50 = 4300.0 nM 5.37
CHEMBL4446055 — IC50 = 4900.0 nM 5.31
CHEMBL4590591 — IC50 = 5400.0 nM 5.27
CHEMBL3924724 — IC50 = 6300.0 nM 5.20
CHEMBL4453551 — IC50 = 6500.0 nM 5.19
CHEMBL4447455 — IC50 = 6400.0 nM 5.19
CHEMBL3908434 — IC50 = 6400.0 nM 5.19
CHEMBL3951335 — IC50 = 7000.0 nM 5.16
CHEMBL4542408 — IC50 = 6900.0 nM 5.16
CHEMBL4518473 — IC50 = 6900.0 nM 5.16
CHEMBL4548710 — IC50 = 6900.0 nM 5.16
CHEMBL4533148 — IC50 = 7200.0 nM 5.14
CHEMBL4169499 — IC50 = 7600.0 nM 5.12
CHEMBL4166077 — IC50 = 7600.0 nM 5.12
CHEMBL4161487 — IC50 = 7600.0 nM 5.12
CHEMBL4531689 — IC50 = 7900.0 nM 5.10
CHEMBL3980253 — IC50 = 8000.0 nM 5.10
CHEMBL4167333 — IC50 = 8000.0 nM 5.10
CHEMBL4565697 — IC50 = 7900.0 nM 5.10
CHEMBL3975683 — IC50 = 8100.0 nM 5.09
CHEMBL4467368 — IC50 = 8400.0 nM 5.08
CHEMBL4547546 — IC50 = 8600.0 nM 5.07
CHEMBL4513892 — IC50 = 8800.0 nM 5.06
CHEMBL4161583 — IC50 = 9400.0 nM 5.03
CHEMBL4562570 — IC50 = 10000.0 nM 5.00
CHEMBL3912547 — IC50 = 10000.0 nM 5.00
CHEMBL3960743 — IC50 = 10000.0 nM 5.00
CHEMBL4526007 — IC50 = 10000.0 nM 5.00
CHEMBL4583291 — IC50 = 11000.0 nM 4.96
CHEMBL4162794 — IC50 = 11000.0 nM 4.96
CHEMBL3952045 — IC50 = 11000.0 nM 4.96
CHEMBL4531228 — IC50 = 11000.0 nM 4.96
CHEMBL3979736 — IC50 = 11000.0 nM 4.96
CHEMBL4531772 — IC50 = 11000.0 nM 4.96
CHEMBL3970551 — IC50 = 12000.0 nM 4.92
CHEMBL4160098 — IC50 = 12000.0 nM 4.92
CHEMBL3950773 — IC50 = 12000.0 nM 4.92
CHEMBL3978830 — IC50 = 12000.0 nM 4.92
CHEMBL4545651 — IC50 = 12000.0 nM 4.92
CHEMBL4522496 — IC50 = 12000.0 nM 4.92
CHEMBL3890411 — IC50 = 13000.0 nM 4.89
CHEMBL4449994 — IC50 = 13000.0 nM 4.89
CHEMBL4463085 — IC50 = 13000.0 nM 4.89
CHEMBL4176697 — IC50 = 13000.0 nM 4.89
CHEMBL3928317 — IC50 = 14000.0 nM 4.85
CHEMBL4437169 — IC50 = 14000.0 nM 4.85
CHEMBL4449196 — IC50 = 14000.0 nM 4.85
CHEMBL3899371 — IC50 = 14000.0 nM 4.85
CHEMBL1389174 — IC50 = 14000.0 nM 4.85