Assay Detail
Binding
CHEMBL4388644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HSP60 expressed in Escherichia coli Rosetta 2(DE3)/human HSP10 expressed in Escherichia coli Rosetta 2(DE3) pLysS cells assessed as reduction in HSP60/HSP10-mediated denatured pig heart mitochondrial MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 40 to 60 mins by spectrometric analysis
72
Total Activities
72
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 72 | 4.38 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437169 | — | — | 1 | 5.05 |
| CHEMBL4463085 | — | — | 1 | 5.04 |
| CHEMBL4561738 | — | — | 1 | 4.92 |
| CHEMBL4168023 | — | — | 1 | 4.89 |
| CHEMBL3986320 | — | — | 1 | 4.85 |
| CHEMBL4449221 | — | — | 1 | 4.77 |
| CHEMBL4556062 | — | — | 1 | 4.77 |
| CHEMBL3938421 | — | — | 1 | 4.77 |
| CHEMBL3910488 | — | — | 1 | 4.75 |
| CHEMBL4563828 | — | — | 1 | 4.60 |
| CHEMBL4461900 | — | — | 1 | 4.55 |
| CHEMBL4567343 | — | — | 1 | 4.51 |
| CHEMBL4168415 | — | — | 1 | 4.43 |
| CHEMBL3975456 | — | — | 1 | 4.40 |
| CHEMBL4573394 | — | — | 1 | 4.37 |
| CHEMBL4176281 | — | — | 1 | 4.32 |
| CHEMBL3906378 | — | — | 1 | 4.31 |
| CHEMBL4583096 | — | — | 1 | 4.30 |
| CHEMBL4513591 | — | — | 1 | 4.27 |
| CHEMBL4461747 | — | — | 1 | 4.24 |
| CHEMBL3922861 | — | — | 1 | 4.24 |
| CHEMBL4440705 | — | — | 1 | 4.21 |
| CHEMBL4567422 | — | — | 1 | 4.21 |
| CHEMBL4542758 | — | — | 1 | 4.20 |
| CHEMBL3913878 | — | — | 1 | 4.17 |
| CHEMBL4434992 | — | — | 1 | 4.16 |
| CHEMBL4463791 | — | — | 1 | 4.16 |
| CHEMBL4565061 | — | — | 1 | 4.15 |
| CHEMBL4562717 | — | — | 1 | 4.14 |
| CHEMBL4462640 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437169 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4463085 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4561738 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4168023 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3986320 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4449221 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4556062 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3938421 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3910488 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4563828 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4461900 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4567343 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4168415 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3975456 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4573394 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4176281 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3906378 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4583096 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4513591 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4461747 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL3922861 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4440705 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL4567422 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL4542758 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL3913878 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL4434992 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL4463791 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4565061 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4562717 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL4462640 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL4458221 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL4458229 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL3903813 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4447680 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4570232 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL4434972 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL4464897 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL4443896 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL1587605 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4541977 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4446756 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4567660 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4454247 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4462237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4532359 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4564122 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4574391 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4457015 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4449832 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4450124 | — | IC50 | > | 100000.0 | nM | - |