Assay Detail
Binding
CHEMBL4390040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human amyloid beta (1 to 40) assessed as reduction in aggregation measured after 24 hrs by ThT fluorescence assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Naturally occurring biflavonoids with amyloid β aggregation inhibitory activity for development of anti-Alzheimer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.95 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164 | MYRICETIN | — | 1 | 5.39 |
| CHEMBL378188 | BILOBETIN | — | 1 | 5.33 |
| CHEMBL63354 | AMENTOFLAVONE | — | 1 | 5.32 |
| CHEMBL220745 | PODOCARPUSFLAVONE A | — | 1 | 5.31 |
| CHEMBL255493 | SEQUOIAFLAVONE | — | 1 | 5.31 |
| CHEMBL291426 | HINOKIFLAVONE | — | 1 | 5.02 |
| CHEMBL1208903 | ISOGINKGETIN | — | 1 | 5.00 |
| CHEMBL4449738 | — | — | 1 | 4.89 |
| CHEMBL377324 | GINKGETIN | — | 1 | 4.88 |
| CHEMBL4554693 | — | — | 1 | 4.80 |
| CHEMBL4463033 | — | — | 1 | 4.76 |
| CHEMBL374055 | 7'',4'''-dimethylamentoflavone | — | 1 | 4.70 |
| CHEMBL3589107 | — | — | 1 | 4.67 |
| CHEMBL4545404 | — | — | 1 | 4.48 |
| CHEMBL4513568 | — | — | 1 | 4.34 |
| CHEMBL4522982 | — | — | 1 | - |
| CHEMBL450522 | SOTETSUFLAVONE | — | 1 | - |
| CHEMBL28 | APIGENIN | — | 1 | - |
| CHEMBL1208904 | HEVEAFLAVONE | — | 1 | - |
| CHEMBL208988 | — | — | 1 | - |
| CHEMBL208578 | — | — | 1 | - |
| CHEMBL208908 | SCIADOPITISIN | — | 1 | - |
| CHEMBL4589690 | — | — | 1 | - |
| CHEMBL453479 | KAYAFLAVONE | — | 1 | - |
| CHEMBL378516 | — | — | 1 | - |
| CHEMBL451902 | — | — | 1 | - |
| CHEMBL4536141 | — | — | 1 | - |
| CHEMBL3589106 | — | — | 1 | - |
| CHEMBL3589108 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164 | MYRICETIN | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL378188 | BILOBETIN | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL63354 | AMENTOFLAVONE | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL220745 | PODOCARPUSFLAVONE A | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL255493 | SEQUOIAFLAVONE | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL291426 | HINOKIFLAVONE | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1208903 | ISOGINKGETIN | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4449738 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL377324 | GINKGETIN | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4554693 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4463033 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL374055 | 7'',4'''-dimethylamentoflavone | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL3589107 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL4545404 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL4513568 | — | IC50 | = | 45600.0 | nM | 4.34 |
| CHEMBL4522982 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL450522 | SOTETSUFLAVONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL28 | APIGENIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL1208904 | HEVEAFLAVONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL208988 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL208578 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL208908 | SCIADOPITISIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL4589690 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL453479 | KAYAFLAVONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL378516 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL451902 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4536141 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3589106 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3589108 | — | IC50 | > | 50000.0 | nM | - |