Assay Detail
Binding
CHEMBL4390974
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Inhibition of Schistosoma mansoni DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Schistosoma mansoni |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL4523950) ↗| Type | SINGLE PROTEIN |
| Organism | Schistosoma mansoni |
Publication
Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.88 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4540838 | — | — | 1 | 7.72 |
| CHEMBL15193 | LAPACHOL | — | 1 | 7.72 |
| CHEMBL155771 | — | — | 1 | 7.64 |
| CHEMBL4452960 | — | — | 1 | 7.11 |
| CHEMBL4472078 | — | — | 1 | 6.96 |
| CHEMBL4457147 | — | — | 1 | 6.89 |
| CHEMBL4560384 | — | — | 1 | 6.73 |
| CHEMBL4474026 | — | — | 1 | 6.64 |
| CHEMBL4527976 | — | — | 1 | 6.43 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 6.37 |
| CHEMBL4586212 | — | — | 1 | 6.36 |
| CHEMBL2041119 | — | — | 1 | 6.15 |
| CHEMBL4566973 | — | — | 1 | 6.00 |
| CHEMBL62718 | — | — | 1 | 5.92 |
| CHEMBL4546952 | — | — | 1 | 5.68 |
| CHEMBL2408377 | — | — | 1 | 5.68 |
| CHEMBL4436314 | — | — | 1 | 5.60 |
| CHEMBL2408378 | — | — | 1 | 5.33 |
| CHEMBL4524841 | — | — | 1 | 5.26 |
| CHEMBL8320 | BENZOQUINONE | — | 1 | 5.06 |
| CHEMBL2408379 | — | — | 1 | 5.00 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 4.70 |
| CHEMBL240963 | LAWSONE | — | 1 | 4.54 |
| CHEMBL2023282 | — | — | 1 | 4.50 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 4.30 |
| CHEMBL358225 | Cresoquinone | — | 1 | 4.24 |
| CHEMBL4464250 | — | — | 1 | 4.10 |
| CHEMBL2252966 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4540838 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL15193 | LAPACHOL | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL155771 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4452960 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4472078 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4457147 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4560384 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4474026 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL4527976 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL4586212 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL2041119 | — | IC50 | = | 711.0 | nM | 6.15 |
| CHEMBL4566973 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL62718 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4546952 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2408377 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4436314 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2408378 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4524841 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL8320 | BENZOQUINONE | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL2408379 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL240963 | LAWSONE | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2023282 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL358225 | Cresoquinone | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4464250 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL2252966 | — | IC50 | = | 768000.0 | nM | - |