Assay Detail
Binding
CHEMBL4391165
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Inhibition of human serum BChE using BTCh as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by Ellman's method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.89 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4537026 | — | — | 1 | 7.68 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.47 |
| CHEMBL4593316 | — | — | 1 | 7.18 |
| CHEMBL4516356 | — | — | 1 | 6.77 |
| CHEMBL4583650 | — | — | 1 | 6.73 |
| CHEMBL4446287 | — | — | 1 | 6.69 |
| CHEMBL4443468 | — | — | 1 | 6.59 |
| CHEMBL4559936 | — | — | 1 | 6.52 |
| CHEMBL4443989 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4537026 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL95 | TACRINE | IC50 | = | 33.5 | nM | 7.47 |
| CHEMBL4593316 | — | IC50 | = | 65.7 | nM | 7.18 |
| CHEMBL4516356 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4583650 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4446287 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL4443468 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL4559936 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL4443989 | — | IC50 | = | 395.0 | nM | 6.40 |