Assay Detail
Functional
CHEMBL4391689
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Cytotoxicity against human HCT116 cells assessed as reduction in cell growth measured after 72 hrs by MTS assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.48 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458738 | — | — | 1 | 10.15 |
| CHEMBL4439731 | — | — | 1 | 9.70 |
| CHEMBL4537169 | — | — | 1 | 8.97 |
| CHEMBL4529498 | — | — | 1 | 8.76 |
| CHEMBL498271 | — | — | 1 | 8.74 |
| CHEMBL4547599 | — | — | 1 | 8.70 |
| CHEMBL4586662 | — | — | 1 | 8.62 |
| CHEMBL4578717 | — | — | 1 | 8.54 |
| CHEMBL4439828 | — | — | 1 | 8.48 |
| CHEMBL4549014 | — | — | 1 | 7.92 |
| CHEMBL4474720 | — | — | 1 | 7.78 |
| CHEMBL4442698 | — | — | 1 | 7.68 |
| CHEMBL4591246 | — | — | 1 | 7.67 |
| CHEMBL4521487 | — | — | 1 | 7.61 |
| CHEMBL4446526 | — | — | 1 | 7.30 |
| CHEMBL4453423 | — | — | 1 | 6.73 |
| CHEMBL4583110 | — | — | 1 | 6.69 |
| CHEMBL4469406 | — | — | 1 | 6.66 |
| CHEMBL4572442 | — | — | 1 | 6.34 |
| CHEMBL4450753 | — | — | 1 | 6.32 |
| CHEMBL4466814 | — | — | 1 | 6.21 |
| CHEMBL4538146 | — | — | 1 | 6.07 |
| CHEMBL4570775 | — | — | 1 | 6.07 |
| CHEMBL4562104 | — | — | 1 | 6.06 |
| CHEMBL4441319 | — | — | 1 | 6.05 |
| CHEMBL4459082 | — | — | 1 | 6.03 |
| CHEMBL4515230 | — | — | 1 | 6.01 |
| CHEMBL4536779 | — | — | 1 | - |
| CHEMBL4456533 | — | — | 1 | - |
| CHEMBL4475510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458738 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL4439731 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4537169 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL4529498 | — | IC50 | = | 1.73 | nM | 8.76 |
| CHEMBL498271 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4547599 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4586662 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4578717 | — | IC50 | = | 2.88 | nM | 8.54 |
| CHEMBL4439828 | — | IC50 | = | 3.28 | nM | 8.48 |
| CHEMBL4549014 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4474720 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL4442698 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL4591246 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL4521487 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL4446526 | — | IC50 | = | 50.6 | nM | 7.30 |
| CHEMBL4453423 | — | IC50 | = | 186.1 | nM | 6.73 |
| CHEMBL4583110 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL4469406 | — | IC50 | = | 219.2 | nM | 6.66 |
| CHEMBL4572442 | — | IC50 | = | 461.8 | nM | 6.34 |
| CHEMBL4450753 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL4466814 | — | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL4538146 | — | IC50 | = | 843.6 | nM | 6.07 |
| CHEMBL4570775 | — | IC50 | = | 847.0 | nM | 6.07 |
| CHEMBL4562104 | — | IC50 | = | 879.0 | nM | 6.06 |
| CHEMBL4441319 | — | IC50 | = | 891.0 | nM | 6.05 |
| CHEMBL4459082 | — | IC50 | = | 943.0 | nM | 6.03 |
| CHEMBL4515230 | — | IC50 | = | 969.0 | nM | 6.01 |
| CHEMBL4536779 | — | IC50 | - | — | - | |
| CHEMBL4456533 | — | IC50 | - | — | - | |
| CHEMBL4475510 | — | IC50 | - | — | - |