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Assay Detail

CHEMBL4391798

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ADMET
Cytotoxicity against human WI38 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
ChEMBL ↗
52
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type WI-38
Confidence 1 — Organism
Curated By Autocuration

Target

WI-38 (CHEMBL614391) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of novel α-acyloxy carboxamides via Passerini reaction as caspase 3/7 activators.
Salah Ayoup M, Wahby Y, Abdel-Hamid H, Ramadan ES, Teleb M, Abu-Serie MM, Noby A.
Eur J Med Chem (2019) 168 : 340 -356
PubMed 30826510 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.87 7.58
EC100 26 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 2 7.58
CHEMBL4582711 — — 2 7.50
CHEMBL4452355 — — 2 7.46
CHEMBL4581075 — — 2 7.46
CHEMBL4474493 — — 2 7.40
CHEMBL4476481 — — 2 7.39
CHEMBL4470597 — — 2 7.36
CHEMBL4542198 — — 2 7.35
CHEMBL4531962 — — 2 7.33
CHEMBL4451006 — — 2 7.33
CHEMBL4444346 — — 2 7.32
CHEMBL4517018 — — 2 7.27
CHEMBL4572642 — — 2 7.07
CHEMBL4587937 — — 2 6.73
CHEMBL4579034 — — 2 6.69
CHEMBL4457766 — — 2 6.61
CHEMBL3194066 — — 2 6.50
CHEMBL4561108 — — 2 6.45
CHEMBL4457138 — — 2 6.45
CHEMBL4452570 — — 2 6.41
CHEMBL4464653 — — 2 6.41
CHEMBL4451398 — — 2 6.40
CHEMBL4455197 — — 2 6.28
CHEMBL4483079 — — 2 6.12
CHEMBL4516932 — — 2 5.91
CHEMBL4474327 — — 2 5.71

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 26.6 nM 7.58
CHEMBL4582711 — IC50 = 32.0 nM 7.50
CHEMBL4581075 — IC50 = 34.6 nM 7.46
CHEMBL4452355 — IC50 = 35.0 nM 7.46
CHEMBL4474493 — IC50 = 40.02 nM 7.40
CHEMBL4476481 — IC50 = 41.0 nM 7.39
CHEMBL4470597 — IC50 = 43.9 nM 7.36
CHEMBL4542198 — IC50 = 44.6 nM 7.35
CHEMBL4531962 — IC50 = 46.3 nM 7.33
CHEMBL4451006 — IC50 = 47.0 nM 7.33
CHEMBL4444346 — IC50 = 48.4 nM 7.32
CHEMBL4517018 — IC50 = 53.7 nM 7.27
CHEMBL4572642 — IC50 = 84.4 nM 7.07
CHEMBL4587937 — IC50 = 185.0 nM 6.73
CHEMBL4579034 — IC50 = 203.0 nM 6.69
CHEMBL4457766 — IC50 = 246.0 nM 6.61
CHEMBL3194066 — IC50 = 319.0 nM 6.50
CHEMBL4457138 — IC50 = 355.0 nM 6.45
CHEMBL4561108 — IC50 = 352.0 nM 6.45
CHEMBL4452570 — IC50 = 386.0 nM 6.41
CHEMBL4464653 — IC50 = 386.0 nM 6.41
CHEMBL4451398 — IC50 = 396.0 nM 6.40
CHEMBL4455197 — IC50 = 523.0 nM 6.28
CHEMBL4483079 — IC50 = 761.0 nM 6.12
CHEMBL4516932 — IC50 = 1221.0 nM 5.91
CHEMBL4474327 — IC50 = 1964.0 nM 5.71
CHEMBL53463 DOXORUBICIN EC100 = 0.0121 uM -
CHEMBL4457138 — EC100 = 0.1128 uM -
CHEMBL4474493 — EC100 = 0.0178 uM -
CHEMBL4561108 — EC100 = 0.018 uM -
CHEMBL4455197 — EC100 = 0.0095 uM -
CHEMBL4451398 — EC100 = 0.0247 uM -
CHEMBL4483079 — EC100 = 0.149 uM -
CHEMBL4581075 — EC100 = 0.0067 uM -
CHEMBL4452570 — EC100 = 0.122 uM -
CHEMBL4476481 — EC100 = 0.0197 uM -
CHEMBL4457766 — EC100 = 0.148 uM -
CHEMBL4531962 — EC100 = 0.0271 uM -
CHEMBL4464653 — EC100 = 0.122 uM -
CHEMBL4517018 — EC100 = 0.043 uM -
CHEMBL4451006 — EC100 = 0.0285 uM -
CHEMBL4474327 — EC100 = 0.635 uM -
CHEMBL3194066 — EC100 = 0.157 uM -
CHEMBL4452355 — EC100 = 0.006 uM -
CHEMBL4516932 — EC100 = 0.53 uM -
CHEMBL4579034 — EC100 = 0.02 uM -
CHEMBL4444346 — EC100 = 0.0355 uM -
CHEMBL4470597 — EC100 = 0.032 uM -
CHEMBL4572642 — EC100 = 0.0507 uM -
CHEMBL4542198 — EC100 = 0.0169 uM -