Assay Detail
Binding
CHEMBL4391928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.96 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4540429 | — | — | 1 | 8.41 |
| CHEMBL4589980 | — | — | 1 | 8.11 |
| CHEMBL4556281 | — | — | 1 | 8.04 |
| CHEMBL4559593 | — | — | 1 | 7.89 |
| CHEMBL4556575 | — | — | 1 | 7.64 |
| CHEMBL4559477 | — | — | 1 | 7.60 |
| CHEMBL4438120 | — | — | 1 | 7.40 |
| CHEMBL4555818 | — | — | 1 | 7.28 |
| CHEMBL4467355 | — | — | 1 | 7.26 |
| CHEMBL4459500 | — | — | 1 | 7.25 |
| CHEMBL4456435 | — | — | 1 | 7.19 |
| CHEMBL4563209 | — | — | 1 | 7.13 |
| CHEMBL4586157 | — | — | 1 | 7.11 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.10 |
| CHEMBL4552440 | — | — | 1 | 6.92 |
| CHEMBL4459416 | — | — | 1 | 6.91 |
| CHEMBL4582203 | — | — | 1 | 6.89 |
| CHEMBL4466307 | — | — | 1 | 6.85 |
| CHEMBL4541558 | — | — | 1 | 6.85 |
| CHEMBL4449083 | — | — | 1 | 6.85 |
| CHEMBL4448188 | — | — | 1 | 6.75 |
| CHEMBL4472570 | — | — | 1 | 6.72 |
| CHEMBL4444822 | — | — | 1 | 6.47 |
| CHEMBL4538398 | — | — | 1 | 6.32 |
| CHEMBL4475391 | — | — | 1 | 6.28 |
| CHEMBL3356536 | — | — | 1 | 6.27 |
| CHEMBL4556372 | — | — | 1 | 5.75 |
| CHEMBL292314 | — | — | 1 | 5.75 |
| CHEMBL1256415 | — | — | 1 | 4.75 |
| CHEMBL4580660 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4540429 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4589980 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4556281 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4559593 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4556575 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4559477 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4438120 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4555818 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4467355 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4459500 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4456435 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4563209 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4586157 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL95 | TACRINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4552440 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4459416 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL4582203 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4466307 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4541558 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4449083 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4448188 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4472570 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4444822 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4538398 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4475391 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3356536 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4556372 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL292314 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1256415 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4580660 | — | IC50 | - | — | - | |
| CHEMBL3957176 | — | IC50 | - | — | - |