Assay Detail
Binding
CHEMBL4392265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat C-terminal His-tagged soluble form of CD73 expressed in baculovirus infected Sf9 insect cells using [2,8-3H]AMP as substrate measured after 25 mins by scintillation counting method
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 51 | 6.65 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443977 | — | — | 1 | 8.44 |
| CHEMBL4483379 | — | — | 1 | 7.86 |
| CHEMBL3606064 | — | — | 1 | 7.83 |
| CHEMBL4443094 | — | — | 1 | 7.73 |
| CHEMBL4551648 | — | — | 1 | 7.52 |
| CHEMBL4470616 | — | — | 1 | 7.07 |
| CHEMBL4538320 | — | — | 1 | 7.06 |
| CHEMBL4561816 | — | — | 1 | 7.05 |
| CHEMBL4457058 | — | — | 1 | 7.05 |
| CHEMBL4299847 | — | — | 1 | 6.95 |
| CHEMBL1198914 | — | — | 1 | 6.79 |
| CHEMBL583969 | PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | — | 1 | 6.78 |
| CHEMBL1198873 | — | — | 1 | 6.59 |
| CHEMBL4440236 | — | — | 1 | 6.58 |
| CHEMBL4462889 | — | — | 1 | 6.56 |
| CHEMBL4474742 | — | — | 1 | 6.49 |
| CHEMBL3606109 | — | — | 1 | 6.47 |
| CHEMBL4441328 | — | — | 1 | 6.46 |
| CHEMBL4574475 | — | — | 1 | 6.37 |
| CHEMBL4436640 | — | — | 1 | 6.30 |
| CHEMBL4543740 | — | — | 1 | 6.19 |
| CHEMBL4587157 | — | — | 1 | 6.11 |
| CHEMBL3220831 | — | — | 1 | 6.05 |
| CHEMBL4472359 | — | — | 1 | 5.98 |
| CHEMBL4530172 | — | — | 1 | 5.76 |
| CHEMBL507060 | — | — | 1 | 5.74 |
| CHEMBL3606055 | — | — | 1 | 5.73 |
| CHEMBL4565565 | — | — | 1 | 5.71 |
| CHEMBL4516688 | — | — | 1 | 5.69 |
| CHEMBL4443859 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443977 | — | Ki | = | 3.67 | nM | 8.44 |
| CHEMBL4483379 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL3606064 | — | Ki | = | 14.8 | nM | 7.83 |
| CHEMBL4443094 | — | Ki | = | 18.8 | nM | 7.73 |
| CHEMBL4551648 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL4470616 | — | Ki | = | 85.1 | nM | 7.07 |
| CHEMBL4538320 | — | Ki | = | 86.7 | nM | 7.06 |
| CHEMBL4561816 | — | Ki | = | 88.6 | nM | 7.05 |
| CHEMBL4457058 | — | Ki | = | 88.7 | nM | 7.05 |
| CHEMBL4299847 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL1198914 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL583969 | PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL1198873 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL4440236 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL4462889 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL4474742 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL3606109 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL4441328 | — | Ki | = | 349.0 | nM | 6.46 |
| CHEMBL4574475 | — | Ki | = | 424.0 | nM | 6.37 |
| CHEMBL4436640 | — | Ki | = | 502.0 | nM | 6.30 |
| CHEMBL4543740 | — | Ki | = | 639.0 | nM | 6.19 |
| CHEMBL4587157 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL3220831 | — | Ki | = | 898.0 | nM | 6.05 |
| CHEMBL4472359 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL4530172 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL507060 | — | Ki | = | 1830.0 | nM | 5.74 |
| CHEMBL3606055 | — | Ki | = | 1860.0 | nM | 5.73 |
| CHEMBL4565565 | — | Ki | = | 1970.0 | nM | 5.71 |
| CHEMBL4516688 | — | Ki | = | 2030.0 | nM | 5.69 |
| CHEMBL4458332 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4537717 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4449088 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1198696 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4442307 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4448168 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4471653 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1199783 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4459165 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4442199 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1236535 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4468019 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4451900 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4474595 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4476067 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4463295 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4592397 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4516140 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4587724 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4472287 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4443859 | — | Ki | > | 1000.0 | nM | - |