Assay Detail
Functional
CHEMBL4392279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 10.26 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 11.00 |
| CHEMBL3354594 | — | — | 1 | 10.60 |
| CHEMBL4474284 | — | — | 1 | 10.55 |
| CHEMBL4583231 | — | — | 1 | 10.51 |
| CHEMBL4458988 | — | — | 1 | 10.05 |
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 10.00 |
| CHEMBL4467042 | — | — | 1 | 9.82 |
| CHEMBL3354579 | — | — | 1 | 9.57 |
| CHEMBL3301668 | CARBETOCIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3354594 | — | EC50 | = | 0.025 | nM | 10.60 |
| CHEMBL4474284 | — | EC50 | = | 0.028 | nM | 10.55 |
| CHEMBL4583231 | — | EC50 | = | 0.031 | nM | 10.51 |
| CHEMBL4458988 | — | EC50 | = | 0.089 | nM | 10.05 |
| CHEMBL373742 | VASOPRESSIN | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4467042 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3354579 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL3301668 | CARBETOCIN | EC50 | = | 0.01 | nM | - |