Assay Detail
Binding
CHEMBL4392280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hr
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.91 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474284 | — | — | 1 | 9.29 |
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 9.24 |
| CHEMBL4458988 | — | — | 1 | 9.05 |
| CHEMBL3354594 | — | — | 1 | 8.96 |
| CHEMBL3354579 | — | — | 1 | 8.85 |
| CHEMBL4583231 | — | — | 1 | 8.85 |
| CHEMBL3301668 | CARBETOCIN | 3.0 | 1 | 8.74 |
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 8.70 |
| CHEMBL4467042 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474284 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL395429 | OXYTOCIN | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL4458988 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL3354594 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3354579 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4583231 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL3301668 | CARBETOCIN | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL373742 | VASOPRESSIN | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4467042 | — | Ki | = | 3.0 | nM | 8.52 |