Assay Detail
ADMET
CHEMBL4392282
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Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.71 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474284 | — | — | 1 | 9.30 |
| CHEMBL4458988 | — | — | 1 | 9.10 |
| CHEMBL3301668 | CARBETOCIN | 3.0 | 1 | 8.32 |
| CHEMBL3354579 | — | — | 1 | 8.11 |
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | - |
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | - |
| CHEMBL3354594 | — | — | 1 | - |
| CHEMBL4583231 | — | — | 1 | - |
| CHEMBL4467042 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474284 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4458988 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3301668 | CARBETOCIN | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3354579 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL395429 | OXYTOCIN | EC50 | = | 0.24 | nM | - |
| CHEMBL373742 | VASOPRESSIN | EC50 | = | 0.0035 | nM | - |
| CHEMBL3354594 | — | EC50 | > | 10.0 | nM | - |
| CHEMBL4583231 | — | EC50 | > | 10.0 | nM | - |
| CHEMBL4467042 | — | EC50 | > | 10.0 | nM | - |