Assay Detail
Functional
CHEMBL4392472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3 infected in human MT2 cells assessed as reduction in viral yield measured after 4 days by EnduRen live cell substrate based luciferase reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 9.06 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 9.15 |
| CHEMBL4300203 | — | — | 1 | 9.05 |
| CHEMBL4522729 | — | — | 1 | 9.05 |
| CHEMBL4437104 | — | — | 1 | 9.05 |
| CHEMBL4474072 | — | — | 1 | 9.05 |
| CHEMBL4460401 | — | — | 1 | 9.05 |
| CHEMBL4554438 | — | — | 1 | 9.05 |
| CHEMBL4447493 | — | — | 1 | 9.05 |
| CHEMBL4463796 | — | — | 1 | 9.05 |
| CHEMBL4525849 | — | — | 1 | 9.05 |
| CHEMBL4542773 | — | — | 1 | 9.05 |
| CHEMBL4573907 | — | — | 1 | 9.05 |
| CHEMBL4574382 | — | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4300203 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4522729 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4437104 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4474072 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4460401 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4554438 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4447493 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4463796 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4525849 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4542773 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4573907 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4574382 | — | EC50 | = | 0.9 | nM | 9.05 |