Assay Detail
Binding
CHEMBL4392490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DGAT1
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 8.06 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4585408 | — | — | 1 | 9.15 |
| CHEMBL4453443 | — | — | 1 | 8.89 |
| CHEMBL4467163 | — | — | 1 | 8.89 |
| CHEMBL2408632 | — | — | 1 | 8.82 |
| CHEMBL4452940 | — | — | 1 | 8.80 |
| CHEMBL4531443 | — | — | 1 | 8.77 |
| CHEMBL4460750 | — | — | 1 | 8.77 |
| CHEMBL4543944 | — | — | 1 | 8.77 |
| CHEMBL4572398 | — | — | 1 | 8.70 |
| CHEMBL4458847 | — | — | 1 | 8.68 |
| CHEMBL4557603 | — | — | 1 | 8.64 |
| CHEMBL4483357 | — | — | 1 | 8.62 |
| CHEMBL4476596 | — | — | 1 | 8.60 |
| CHEMBL2408633 | — | — | 1 | 8.59 |
| CHEMBL4534257 | — | — | 1 | 8.54 |
| CHEMBL4461148 | — | — | 1 | 8.51 |
| CHEMBL4473500 | — | — | 1 | 8.51 |
| CHEMBL4592144 | — | — | 1 | 8.49 |
| CHEMBL4467830 | — | — | 1 | 8.46 |
| CHEMBL4527253 | — | — | 1 | 8.44 |
| CHEMBL4561313 | — | — | 1 | 8.44 |
| CHEMBL4464262 | — | — | 1 | 8.39 |
| CHEMBL4554202 | — | — | 1 | 8.38 |
| CHEMBL4516271 | — | — | 1 | 8.35 |
| CHEMBL4562424 | — | — | 1 | 8.35 |
| CHEMBL4443023 | — | — | 1 | 8.28 |
| CHEMBL4527223 | — | — | 1 | 8.28 |
| CHEMBL4461413 | — | — | 1 | 8.27 |
| CHEMBL3342770 | — | — | 1 | 8.24 |
| CHEMBL4443018 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4585408 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4453443 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4467163 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2408632 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4452940 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4531443 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4460750 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4543944 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4572398 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4458847 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4557603 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4483357 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4476596 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2408633 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4534257 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4461148 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4473500 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4592144 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4467830 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4527253 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4561313 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4464262 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4554202 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4516271 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4562424 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4443023 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4527223 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4461413 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3342770 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4443018 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4592655 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4530290 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4461166 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4577468 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4450287 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4453213 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL4469452 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL4069786 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4453600 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4531344 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL4452750 | — | IC50 | = | 26.1 | nM | 7.58 |
| CHEMBL4542552 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL4456729 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4524803 | — | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL4462458 | — | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL4574644 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4453601 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4447657 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4472207 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4525823 | — | IC50 | = | 127.0 | nM | 6.90 |