Compound Detail
CHEMBL4577468
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Basic Information
| ChEMBL ID | CHEMBL4577468 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KMRKVWIQPVPEED-UHFFFAOYSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
455.9
MW (Da)
5.65
ALogP
5
HBA
3
HBD
103.8
PSA (Ų)
0.31
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.6
Ki 1 meas. best 4.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cytochrome P450 2C8 CHEMBL3721 | IC50 | 8.6 | 8.6 | 2.5 | 1 |
| Diacylglycerol O-acyltransferase 1 CHEMBL6009 | IC50 | 8.02 | 8.02 | 9.6 | 1 |
| Diacylglycerol O-acyltransferase 1 CHEMBL1075284 | IC50 | 7.08 | 7.08 | 84.0 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | Ki | 4.92 | 4.92 | 11890.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cytochrome P450 2C8 | IC50 | = | 2.5 | nM | 8.6 | Inhibition of CYP2C8 (unknown origin) | 30952592 |
| Diacylglycerol O-acyltransferase 1 | IC50 | = | 9.6 | nM | 8.02 | Inhibition of human DGAT1 | 30952592 |
| Diacylglycerol O-acyltransferase 1 | IC50 | = | 84.0 | nM | 7.08 | Inhibition of mouse DGAT1 | 30952592 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | Ki | = | 11890.0 | nM | 4.92 | Inhibition of human ERG | 30952592 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30952592 | 10.1016/j.bmcl.2019.03.039 | Diacylglycerol O-acyltransferase 1 | 2 |
| 30952592 | 10.1016/j.bmcl.2019.03.039 | Sterol O-acyltransferase 1 | 1 |
| 30952592 | 10.1016/j.bmcl.2019.03.039 | No relevant target | 1 |
| 30952592 | 10.1016/j.bmcl.2019.03.039 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 30952592 | 10.1016/j.bmcl.2019.03.039 | Mus musculus | 1 |
| 30952592 | 10.1016/j.bmcl.2019.03.039 | Cytochrome P450 2C8 | 1 |
Data from ChEMBL 36 via Core Engine