Assay Detail
Binding
CHEMBL4392494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 49 | 5.24 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447657 | — | — | 1 | 6.37 |
| CHEMBL4472207 | — | — | 1 | 6.21 |
| CHEMBL4453601 | — | — | 1 | 6.09 |
| CHEMBL4467163 | — | — | 1 | 5.87 |
| CHEMBL4525823 | — | — | 1 | 5.85 |
| CHEMBL4575608 | — | — | 1 | 5.79 |
| CHEMBL4562424 | — | — | 1 | 5.76 |
| CHEMBL4516271 | — | — | 1 | 5.70 |
| CHEMBL4443018 | — | — | 1 | 5.65 |
| CHEMBL4541477 | — | — | 1 | 5.64 |
| CHEMBL4561313 | — | — | 1 | 5.57 |
| CHEMBL4452750 | — | — | 1 | 5.52 |
| CHEMBL4453443 | — | — | 1 | 5.52 |
| CHEMBL4554202 | — | — | 1 | 5.45 |
| CHEMBL2408633 | — | — | 1 | 5.45 |
| CHEMBL4461413 | — | — | 1 | 5.43 |
| CHEMBL4458847 | — | — | 1 | 5.42 |
| CHEMBL4464262 | — | — | 1 | 5.39 |
| CHEMBL4452940 | — | — | 1 | 5.39 |
| CHEMBL4473500 | — | — | 1 | 5.35 |
| CHEMBL4476596 | — | — | 1 | 5.32 |
| CHEMBL4572398 | — | — | 1 | 5.31 |
| CHEMBL4450287 | — | — | 1 | 5.28 |
| CHEMBL2408632 | — | — | 1 | 5.27 |
| CHEMBL4527223 | — | — | 1 | 5.18 |
| CHEMBL4483357 | — | — | 1 | 5.09 |
| CHEMBL4585408 | — | — | 1 | 5.09 |
| CHEMBL4592144 | — | — | 1 | 5.07 |
| CHEMBL4461148 | — | — | 1 | 4.97 |
| CHEMBL4461166 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447657 | — | Ki | = | 426.0 | nM | 6.37 |
| CHEMBL4472207 | — | Ki | = | 616.0 | nM | 6.21 |
| CHEMBL4453601 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL4467163 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL4525823 | — | Ki | = | 1427.0 | nM | 5.85 |
| CHEMBL4575608 | — | Ki | = | 1641.0 | nM | 5.79 |
| CHEMBL4562424 | — | Ki | = | 1740.0 | nM | 5.76 |
| CHEMBL4516271 | — | Ki | = | 1980.0 | nM | 5.70 |
| CHEMBL4443018 | — | Ki | = | 2250.0 | nM | 5.65 |
| CHEMBL4541477 | — | Ki | = | 2314.0 | nM | 5.64 |
| CHEMBL4561313 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL4452750 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4453443 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4554202 | — | Ki | = | 3560.0 | nM | 5.45 |
| CHEMBL2408633 | — | Ki | = | 3520.0 | nM | 5.45 |
| CHEMBL4461413 | — | Ki | = | 3750.0 | nM | 5.43 |
| CHEMBL4458847 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL4464262 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL4452940 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL4473500 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL4476596 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL4572398 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL4450287 | — | Ki | = | 5220.0 | nM | 5.28 |
| CHEMBL2408632 | — | Ki | = | 5390.0 | nM | 5.27 |
| CHEMBL4527223 | — | Ki | = | 6540.0 | nM | 5.18 |
| CHEMBL4585408 | — | Ki | = | 8140.0 | nM | 5.09 |
| CHEMBL4483357 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL4592144 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL4461148 | — | Ki | = | 10750.0 | nM | 4.97 |
| CHEMBL4461166 | — | Ki | = | 10700.0 | nM | 4.97 |
| CHEMBL4577468 | — | Ki | = | 11890.0 | nM | 4.92 |
| CHEMBL4531344 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL4534257 | — | Ki | = | 12120.0 | nM | 4.92 |
| CHEMBL4574644 | — | Ki | = | 13040.0 | nM | 4.88 |
| CHEMBL4543944 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL4527253 | — | Ki | = | 18980.0 | nM | 4.72 |
| CHEMBL4460750 | — | Ki | = | 20050.0 | nM | 4.70 |
| CHEMBL4467830 | — | Ki | = | 20230.0 | nM | 4.69 |
| CHEMBL4524803 | — | Ki | = | 20500.0 | nM | 4.69 |
| CHEMBL4530290 | — | Ki | = | 23400.0 | nM | 4.63 |
| CHEMBL4469452 | — | Ki | = | 25700.0 | nM | 4.59 |
| CHEMBL4443023 | — | Ki | = | 26900.0 | nM | 4.57 |
| CHEMBL4453213 | — | Ki | = | 37700.0 | nM | 4.42 |
| CHEMBL4592655 | — | Ki | = | 40700.0 | nM | 4.39 |
| CHEMBL4542552 | — | Ki | > | 60000.0 | nM | - |
| CHEMBL4453600 | — | Ki | > | 60000.0 | nM | - |
| CHEMBL4456729 | — | Ki | > | 60000.0 | nM | - |
| CHEMBL4462458 | — | Ki | - | — | - | |
| CHEMBL4565611 | — | Ki | - | — | - |