Assay Detail
Binding
CHEMBL4392491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse DGAT1
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Diacylglycerol O-acyltransferase 1 (CHEMBL1075284) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.77 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4585408 | — | — | 1 | 8.85 |
| CHEMBL4452940 | — | — | 1 | 8.82 |
| CHEMBL4531443 | — | — | 1 | 8.77 |
| CHEMBL4453443 | — | — | 1 | 8.77 |
| CHEMBL4557603 | — | — | 1 | 8.74 |
| CHEMBL4458847 | — | — | 1 | 8.64 |
| CHEMBL4543944 | — | — | 1 | 8.59 |
| CHEMBL2408632 | — | — | 1 | 8.55 |
| CHEMBL4483357 | — | — | 1 | 8.49 |
| CHEMBL4467163 | — | — | 1 | 8.36 |
| CHEMBL4572398 | — | — | 1 | 8.34 |
| CHEMBL4460750 | — | — | 1 | 8.30 |
| CHEMBL4443023 | — | — | 1 | 8.28 |
| CHEMBL4592144 | — | — | 1 | 8.23 |
| CHEMBL2408633 | — | — | 1 | 8.20 |
| CHEMBL4530290 | — | — | 1 | 8.02 |
| CHEMBL4453213 | — | — | 1 | 8.01 |
| CHEMBL4464262 | — | — | 1 | 7.96 |
| CHEMBL4461148 | — | — | 1 | 7.96 |
| CHEMBL4561313 | — | — | 1 | 7.75 |
| CHEMBL4534257 | — | — | 1 | 7.70 |
| CHEMBL4476596 | — | — | 1 | 7.70 |
| CHEMBL4554202 | — | — | 1 | 7.68 |
| CHEMBL4461166 | — | — | 1 | 7.67 |
| CHEMBL4473500 | — | — | 1 | 7.66 |
| CHEMBL4467830 | — | — | 1 | 7.62 |
| CHEMBL4527253 | — | — | 1 | 7.52 |
| CHEMBL4562424 | — | — | 1 | 7.48 |
| CHEMBL4516271 | — | — | 1 | 7.44 |
| CHEMBL4527223 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4585408 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4452940 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4453443 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4531443 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4557603 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4458847 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4543944 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2408632 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4483357 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4467163 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4572398 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4460750 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4443023 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4592144 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL2408633 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4530290 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4453213 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4464262 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4461148 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4561313 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL4476596 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4534257 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4554202 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4461166 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL4473500 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4467830 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4527253 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4562424 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4516271 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4527223 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4542552 | — | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL4469452 | — | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL4592655 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4461413 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4524803 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4577468 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4450287 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4531344 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4453600 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL4462458 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL4452750 | — | IC50 | = | 528.0 | nM | 6.28 |
| CHEMBL4565611 | — | IC50 | = | 1908.0 | nM | 5.72 |