Assay Detail
Functional
CHEMBL4392525
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Growth inhibition of human HCT116 cells measured after 72 hrs by phosphatase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.56 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472320 | — | — | 1 | 10.17 |
| CHEMBL4442023 | — | — | 1 | 10.13 |
| CHEMBL4454735 | — | — | 1 | 10.12 |
| CHEMBL2441610 | — | — | 1 | 9.22 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472320 | — | IC50 | = | 0.067 | nM | 10.17 |
| CHEMBL4442023 | — | IC50 | = | 0.074 | nM | 10.13 |
| CHEMBL4454735 | — | IC50 | = | 0.075 | nM | 10.12 |
| CHEMBL2441610 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6.8 | nM | 8.17 |