Assay Detail
Binding
CHEMBL4392554
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Inhibition of PRMT5 (unknown origin)
13
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 5 (CHEMBL1795116) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.95 | 9.00 |
| Ki | 1 | 10.70 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441584 | — | — | 1 | 10.70 |
| CHEMBL4455651 | — | — | 2 | 9.00 |
| CHEMBL4470815 | — | — | 1 | 9.00 |
| CHEMBL4448266 | — | — | 1 | 9.00 |
| CHEMBL4563402 | — | — | 1 | 9.00 |
| CHEMBL4547524 | — | — | 1 | 9.00 |
| CHEMBL4541232 | — | — | 1 | 9.00 |
| CHEMBL4445368 | — | — | 1 | 9.00 |
| CHEMBL4585734 | — | — | 1 | 9.00 |
| CHEMBL4517481 | — | — | 1 | 9.00 |
| CHEMBL4579108 | — | — | 1 | 8.70 |
| CHEMBL4460647 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441584 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL4455651 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4455651 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4470815 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4448266 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4563402 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4547524 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4541232 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4445368 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4585734 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4517481 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4579108 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4460647 | — | IC50 | = | 2.0 | nM | 8.70 |