Assay Detail
Functional
CHEMBL4392557
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Antiproliferative activity against human A549 cells incubated for 7 days with compound replacement on day 4 by cell titer glo-based luminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.57 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4585781 | — | — | 1 | 8.30 |
| CHEMBL4472087 | — | — | 1 | 8.22 |
| CHEMBL4453587 | — | — | 1 | 8.00 |
| CHEMBL4582424 | — | — | 1 | 7.80 |
| CHEMBL4460965 | — | — | 1 | 7.32 |
| CHEMBL4557058 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4585781 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4472087 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4453587 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4582424 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4460965 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4557058 | — | IC50 | = | 1785.0 | nM | 5.75 |