Compound Detail
CHEMBL4472087
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Nc1ncnc2c1ccn2[C@@H]1O[C@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O
Basic Information
| ChEMBL ID | CHEMBL4472087 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YDGIDMHKHFFVPX-QFRSUPTLSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
378.3
MW (Da)
0.64
ALogP
8
HBA
4
HBD
126.7
PSA (Ų)
0.53
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PRMT5/MEP50 complex CHEMBL3137261 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| A549 CHEMBL392 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PRMT5/MEP50 complex | IC50 | = | 1.0 | nM | 9.0 | Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (u... | 30956011 |
| Unchecked | IC50 | = | 1.0 | nM | 9.0 | PRMT5 assay: Compounds were solubilized in DMSO and serially diluted, using 3-fo... | - |
| A549 | IC50 | = | 6.0 | nM | 8.22 | Antiproliferative activity against human A549 cells incubated for 7 days with co... | 30956011 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30956011 | 10.1016/j.bmcl.2019.03.042 | A549 | 1 |
| 30956011 | 10.1016/j.bmcl.2019.03.042 | PRMT5/MEP50 complex | 1 |
Data from ChEMBL 36 via Core Engine