Assay Detail
Binding
CHEMBL4392562
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Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immunohistochemistry method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 5 (CHEMBL1795116) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.20 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4541714 | — | — | 1 | 9.80 |
| CHEMBL4249337 | ONAMETOSTAT | 1.0 | 1 | 9.60 |
| CHEMBL4543007 | — | — | 1 | 9.40 |
| CHEMBL4579773 | — | — | 1 | 8.90 |
| CHEMBL4577464 | — | — | 1 | 8.70 |
| CHEMBL4539612 | — | — | 1 | 8.40 |
| CHEMBL4564327 | — | — | 1 | 8.20 |
| CHEMBL4541070 | — | — | 1 | 8.20 |
| CHEMBL4439077 | — | — | 1 | 8.10 |
| CHEMBL4540972 | — | — | 1 | 7.29 |
| CHEMBL4556400 | — | — | 1 | 7.10 |
| CHEMBL4576734 | — | — | 1 | 6.90 |
| CHEMBL4589179 | — | — | 1 | 5.97 |
| CHEMBL4454890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4541714 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL4249337 | ONAMETOSTAT | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4543007 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4579773 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL4577464 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4539612 | — | IC50 | = | 3.98 | nM | 8.40 |
| CHEMBL4564327 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4541070 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4439077 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4540972 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL4556400 | — | IC50 | = | 79.4 | nM | 7.10 |
| CHEMBL4576734 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4589179 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4454890 | — | IC50 | - | — | - |