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Assay Detail

CHEMBL4392718

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Functional
Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives.
Guan L, Zhou J, Lin Q, Zhu H, Liu W, Liu B, Zhang Y, Zhang J, Gao J, Feng F, Qu W.
Bioorg Med Chem (2019) 27 : 2657 -2665
PubMed 31047774 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.60 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4455240 1 6.60
CHEMBL4467343 1 6.48
CHEMBL4464427 1 6.28
CHEMBL1275656 1 6.28
CHEMBL4467026 1 6.06
CHEMBL4540934 1 6.03
CHEMBL4528624 1 5.92
CHEMBL4572015 1 5.73
CHEMBL374047 MOSCATILIN 1 5.64
CHEMBL87865 1 5.59
CHEMBL4593436 1 5.57
CHEMBL4456013 1 5.53
CHEMBL4457280 1 5.51
CHEMBL555017 GAMBOGIC ACID 1 5.51
CHEMBL4556289 1 5.50
CHEMBL4437036 1 5.43
CHEMBL2093988 1 5.28
CHEMBL4555582 1 5.22
CHEMBL4446253 1 5.21
CHEMBL4458468 1 5.12
CHEMBL4452860 1 5.10
CHEMBL4453803 1 5.06
CHEMBL4571022 1 4.84
CHEMBL4538505 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4455240 IC50 = 250.0 nM 6.60
CHEMBL4467343 IC50 = 330.0 nM 6.48
CHEMBL4464427 IC50 = 530.0 nM 6.28
CHEMBL1275656 IC50 = 520.0 nM 6.28
CHEMBL4467026 IC50 = 880.0 nM 6.06
CHEMBL4540934 IC50 = 930.0 nM 6.03
CHEMBL4528624 IC50 = 1190.0 nM 5.92
CHEMBL4572015 IC50 = 1860.0 nM 5.73
CHEMBL374047 MOSCATILIN IC50 = 2290.0 nM 5.64
CHEMBL87865 IC50 = 2560.0 nM 5.59
CHEMBL4593436 IC50 = 2690.0 nM 5.57
CHEMBL4456013 IC50 = 2980.0 nM 5.53
CHEMBL4457280 IC50 = 3060.0 nM 5.51
CHEMBL555017 GAMBOGIC ACID IC50 = 3110.0 nM 5.51
CHEMBL4556289 IC50 = 3160.0 nM 5.50
CHEMBL4437036 IC50 = 3740.0 nM 5.43
CHEMBL2093988 IC50 = 5260.0 nM 5.28
CHEMBL4555582 IC50 = 5970.0 nM 5.22
CHEMBL4446253 IC50 = 6160.0 nM 5.21
CHEMBL4458468 IC50 = 7570.0 nM 5.12
CHEMBL4452860 IC50 = 7890.0 nM 5.10
CHEMBL4453803 IC50 = 8780.0 nM 5.06
CHEMBL4571022 IC50 = 14530.0 nM 4.84
CHEMBL4538505 IC50 = 15850.0 nM 4.80