Assay Detail
Functional
CHEMBL4392739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus (A/PR/8/34 (H1N1)) infected in MDCK cells assessed as reduction in viral replication preincubated for 1 hr followed by compound washout and measured after 48 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazin-2(1H)-one derivatives as new potent PB2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.58 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | 3.0 | 1 | 8.70 |
| CHEMBL4469834 | — | — | 1 | 5.99 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4469834 | — | EC50 | = | 1025.0 | nM | 5.99 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 9116.0 | nM | 5.04 |