Assay Detail
Functional
CHEMBL4392811
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New phenylpropanoid allopyranosides from the rhizomes of Cimicifuga dahurica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.89 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 5.26 |
| CHEMBL206555 | N-TRANS-FERULOYL TYRAMINE | — | 1 | 5.20 |
| CHEMBL1095920 | CIMICIFUGIC ACID E | — | 1 | 4.71 |
| CHEMBL202844 | N-TRANS-FERULOYLDOPAMINE | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389621 | HYDROCORTISONE | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL206555 | N-TRANS-FERULOYL TYRAMINE | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL1095920 | CIMICIFUGIC ACID E | IC50 | = | 19720.0 | nM | 4.71 |
| CHEMBL202844 | N-TRANS-FERULOYLDOPAMINE | IC50 | = | 39900.0 | nM | 4.40 |